A Dixon Method for Positive Contrast Imaging of Very Small Superparamagnetic Iron Oxide Nanoparticles in MRI

The aim of this project is to develop and validate a Dixon MR imaging technique to achieve positive contrast of very small superparamagnetic iron oxide nanoparticles (VSOPs). We assessed the proposed method in a phantom study and compared the results with three established positive contrast imaging techniques. The reference techniques were GRadient-echo Acquisition for Superparamagnetic particles (GRASP), Inversion Recovery with ON-resonant water suppression (IRON), and Susceptibility Gradient Mapping (SGM). The Dixon method demonstrated superior sensitivity, relative ease of implementation and reliability.

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