Abstract #1740
Optimization of Selective Inversion Recovery Magnetization Transfer Imaging for Clinical Applications
Richard D. Dortch 1,2 , Ke Li 1,2 , Daniel F. Gochberg 1,2 , John C. Gore 1,2 , and Seth A. Smith 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
The goal of this work was to optimize a selective
inversion recovery (SIR) quantitative magnetization
transfer protocol for efficient mapping of myelin
content. To do this, we performed numerical studies to:
i) find optimal sampling strategies and ii) test whether
the MT rate could be held constant during analysis (to
reduce the number of images required to invert the
model). Results in phantoms and healthy brain
demonstrate that SIR parameters can be efficiently and
accurately estimated from as few as four optimized SIR
images. This suggests that optimized SIR protocols may
be viable for clinical applications in the future.
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