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Abstract #1740

Optimization of Selective Inversion Recovery Magnetization Transfer Imaging for Clinical Applications

Richard D. Dortch 1,2 , Ke Li 1,2 , Daniel F. Gochberg 1,2 , John C. Gore 1,2 , and Seth A. Smith 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

The goal of this work was to optimize a selective inversion recovery (SIR) quantitative magnetization transfer protocol for efficient mapping of myelin content. To do this, we performed numerical studies to: i) find optimal sampling strategies and ii) test whether the MT rate could be held constant during analysis (to reduce the number of images required to invert the model). Results in phantoms and healthy brain demonstrate that SIR parameters can be efficiently and accurately estimated from as few as four optimized SIR images. This suggests that optimized SIR protocols may be viable for clinical applications in the future.

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