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Abstract #1741

B 1 -Sensitivity Analysis of qMT

Mathieu Boudreau 1 , Nikola Stikov 1 , and G. Bruce Pike 2

1 McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 2 Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

B 1 mapping is an important measurement used in qMT imaging. For pulsed SPGR qMT imaging experiments, B 1 maps are used as a corrective factor for the excitation flip angle and MT saturation. Inaccuracies in B 1 mapping will propagate to the fitted qMT parameters differently, depending on the B 1 -dependence of the T 1 mapping method. Here we present a simulation-based analysis of the B 1 -sensitivity of qMT, comparing how different T 1 mapping methods (VFA, IR) propagate the B 1 error to the qMT parameters. We show that the pool-size ratio F is very robust to B 1 inaccuracies for VFA, as opposed to IR.

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