Eliminating MT Contribution in Z-Spectra using Dual Band Macromolecular Background Suppression (DBMS)

Chemical Exchange Saturation Transfer (CEST) and Nuclear Overhauser Enhancement (NOE) effects have the potential to transform MRI into a molecular imaging technique. Dual band macromolecular background suppression (DBMS) pulses are designed to saturate two RF frequencies simultaneously. One of the frequency bands provides suppression of the macromolecular contribution across the whole z-spectrum whilst the other sweeps the Z-spectrum. DBMS provides a method to uncouple MT effects from other features of the z-spectrum which will simplify quantification and separation of different z-spectrum features.

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