Abstract #1749
Magnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder
Ziqi Chen 1 , Huawei Zhang 1 , Zhiyun Jia 1,2 , Jingjie Zhong 3 , Xiaoqi Huang 1 , Mingying Du 1 , Lizhou Chen 1 , Weihong Kuang 4 , John A Sweeney 5 , and Qiyong Gong 1
1
Huaxi MR Research Center (HMRRC), Department
of Radiology,West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
2
Department
of Nuclear Medicine, West China Hospital of Sichuan
University, Chengdu, Sichuan, China,
3
Department
of Neurology, West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
4
Department
of Psychiatry, State Key Lab of Biotherapy, West China
Hospital of Sichuan University, Chengdu, Sichuan, China,
5
Departments
of Psychiatry and Pediatrics, University of Texas
Southwestern, Texas, United States
We utilized magnetization transfer imaging to identify
subtle biophysical alterations in MDD with suicidal
behavior. The participants were 36 medication-free MDD
patients, with (N = 17) and without (N = 19) a history
of suicide attempt, and 28 healthy controls.
Magnetization transfer ratio (MTR) was decreased in the
left inferior parietal lobule (IPL) and right superior
parietal lobule (SPL) in suicide attempters relative to
non-attempters and controls. Non-attempters showed
reduced MTR in left IPL and left cerebellum relative to
controls. Attentional dysfunction and impaired decision
making secondary to parietal lobe abnormalities could
increase risk for suicidal behavior in MDD.
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