Meeting Banner
Abstract #1749

Magnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder

Ziqi Chen 1 , Huawei Zhang 1 , Zhiyun Jia 1,2 , Jingjie Zhong 3 , Xiaoqi Huang 1 , Mingying Du 1 , Lizhou Chen 1 , Weihong Kuang 4 , John A Sweeney 5 , and Qiyong Gong 1

1 Huaxi MR Research Center (HMRRC), Department of Radiology,West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 3 Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 4 Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 5 Departments of Psychiatry and Pediatrics, University of Texas Southwestern, Texas, United States

We utilized magnetization transfer imaging to identify subtle biophysical alterations in MDD with suicidal behavior. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of suicide attempt, and 28 healthy controls. Magnetization transfer ratio (MTR) was decreased in the left inferior parietal lobule (IPL) and right superior parietal lobule (SPL) in suicide attempters relative to non-attempters and controls. Non-attempters showed reduced MTR in left IPL and left cerebellum relative to controls. Attentional dysfunction and impaired decision making secondary to parietal lobe abnormalities could increase risk for suicidal behavior in MDD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here