Abstract #1748
Bound water in reconstructed skin samples: quantification by NMR
Genevive Guillot 1 , Sarah Risquez 1 , Chih-Ying Wang 1 , Jean-Baptiste Galey 2 , Marion Ghibaudo 2 , and Bernard Querleux 2
1
CNRS Univ Paris-Sud, IR4M UMR8081, ORSAY,
France,
2
L'Oreal
Research & Innovation, AULNAY-SOUS-BOIS, France
Reconstructed skin samples are routinely used for in
vitro safety and efficacy evaluation of cosmetic
ingredients. MT-NMR is well-suited as a non-destructive
technique for the quantification of the bound proton
fraction. In this work, an off-resonance MT-NMR sequence
was used to characterize dermis from reconstructed skin
samples. A linear relationship between the bound proton
fraction and the solid weight fraction was found with a
slope compatible with 0.2 g of bound water per g of
collagen, in fair agreement with the 4 water molecules
per tripeptide description of collagen hydration.
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