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Abstract #1747

Assessment of membrane fluidity using nuclear Overhauser enhancement mediated magnetization transfer

Xiao-Yong Zhang 1 , Jingping Xie 1 , Hua Li 1 , Junzhong Xu 1 , John C. Gore 1 , and Zhongliang Zu 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

The fluidity of cell membrane is an important characteristic to assess, but to date there are no ways to measure fluidity non-invasively in vivo. We have observed a novel source of contrast at around -1.6 ppm in z-spectra which is derived from nuclear Overhauser enhancement (NOE) effects between water protons and choline methyl protons which are in a restricted state within cell membranes. Our measurements of this signal modulation in different conditions show that NOE-mediated MT signal correlates well with membrane fluidity. This may provide a novel and non-invasive imaging tool to assess changes in membrane fluidity.

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