Cross-relaxation parameter quantification in cortical bone from repeated binomial excitations

Evidence of Magnetization Transfer was recently shown in cortical bone between collagen-bound water protons and collagen methylene protons, as well as a correlation between the amount of collagen methylene protons and mechanical properties. It is then important to quantify cross-relaxation parameters. Our purpose was to highlight Magnetization Transfer using inversion-recovery at two RF durations and repeated binomial excitation. The amount of collagen methylene protons assessed by simulation from the repeated binomial excitation data was in agreement with literature. A repeated binomial excitation can be easily integrated into a UTE sequence and should be used for quantitative Magnetization Transfer in vivo.

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