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Abstract #1745

Multi-parameter mapping of post-mortem lumbar spinal cord tissue in multiple sclerosis

Marco Battiston 1 , Marios C Yiannakas 1 , Jia Newcombe 2 , Claudia A M Wheeler-Kingshott 1 , and Rebecca S Samson 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 NeuroResource Tissue Bank, UCL Institute of Neurology, London, England, United Kingdom

Magnetisation Transfer imaging (MTI) methods are used to probe the macromolecular content of tissue, and find their main application in pathologies involving changes in tissue myelin content, such as multiple sclerosis (MS). Among MTI techniques, those defined as semi-quantitative (i.e. model-free) are most commonly used since they are easy to implement and less time consuming, and therefore more clinically feasible. In this work, a comparison between two semi-quantitative indices, the Magnetisation Transfer Ratio (MTR) and MT sat , calculated using the Multi-Parameter Mapping technique, is performed both in healthy and MS post-mortem spinal cord samples.

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