Abstract #1754
Quantitative CEST (qCEST) using Ωplots in the case of trains of Gaussianshaped saturation pulses
Jan-Eric Meissner 1,2 , Moritz Zaiss 1 , Eugenia Rerich 1 , and Peter Bachert 1
1
Division of Medical Physics in Radiology,
German Cancer Research Center, Heidelberg,
Baden-Wrttemberg, Germany,
2
Neurooncologic
Imaging, Division of Radiology, German Cancer Research
Center, Heidelberg, Baden-Wrttemberg, Germany
The contrast in CEST experiments depends on f
B
,
the concentration of exchanging protons, and on their
exchange rate k
BA
. The Ω-plot method is able
to quantify both simultaneously in the case of cw
saturation. We show that AREX, generating the CEST
contrast in a cw experiment, can be extended to the case
of pulsed CEST. This extension allows to define an
Ωplot method yielding improved estimation of f
B
and
k
BA
also
in the case of saturation by a train of Gaussianshaped
rf pulses. This approach could be the next step towards
quantitative CEST studies
in
vivo
.
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