Meeting Banner
Abstract #1755

Quantitative Assessment of Amide Proton Transfer (APT) and Nuclear Overhauser Enhancement (NOE) Imaging with Extrapolated Semi-solid Magnetization Transfer Reference (EMR) Signals - an Accurate and Straightforward Measurement Approach

Hye-Young Heo 1 , Yi Zhang 1 , Shanshan Jiang 1 , Dong-Hoon Lee 1 , and Jinyuan Zhou 1

1 Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States

APT imaging is important molecular MRI technique that detect endogenous mobile proteins in tissue, such as those in the cytoplasm. To quantitatively assess APT and NOE effects in vivo, a new fitting approach has been introduced, which is based on the extrapolated semi-solid MT model reference signals. The quantitative APT and NOE signals were measured and compared with the commonly used MTRasym(3.5ppm) in human glioma at 3 Tesla. The quantitative results showed that APT signals were significantly higher in the glioma than in the normal tissue and edema, and were the major contributor to the APT-weighted image contrast.

This abstract and the presentation materials are available to members only; a login is required.

Join Here