Optimal Sampling Schedule for PARACEST Agents and Analysis of its Performance
Li Liang 1 , Jing Yuan 2 , Jiadi Xu 3 , and Heather T. Ma 1,4
Department of Electronic and Information
Engineering, Harbin Institute of Technology Shenzhen
Graduate School, Shenzhen, Guangdong, China,
physics and research department, Hong Kong Sanatorium &
Hospital, Hong Kong,
M. Kirby Research Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
Department, Johns Hopkins University, Baltimore, MD,
This study proposed an optimal sampling schedule (OSS)
for PARACEST agents and simulations were conducted to
verify its performance. OSS was calculated by simplified
algorithm associated with average sensitivity curves.
Simulations were performed by fitting noisy z spectra
generated according to prior distribution of model
parameters. Results show that there is a connection
between the performance of OSS and the distribution of
true values of model parameters. The OSS method is able
to provide more accurate parameters comparing to evenly
distributed sampling (EDS) scheme even in the very low
sample number range.
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