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Abstract #1756

Optimal Sampling Schedule for PARACEST Agents and Analysis of its Performance

Li Liang 1 , Jing Yuan 2 , Jiadi Xu 3 , and Heather T. Ma 1,4

1 Department of Electronic and Information Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China, 2 Medical physics and research department, Hong Kong Sanatorium & Hospital, Hong Kong, 3 F. M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 4 Radiology Department, Johns Hopkins University, Baltimore, MD, United States

This study proposed an optimal sampling schedule (OSS) for PARACEST agents and simulations were conducted to verify its performance. OSS was calculated by simplified algorithm associated with average sensitivity curves. Simulations were performed by fitting noisy z spectra generated according to prior distribution of model parameters. Results show that there is a connection between the performance of OSS and the distribution of true values of model parameters. The OSS method is able to provide more accurate parameters comparing to evenly distributed sampling (EDS) scheme even in the very low sample number range.

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