Improved diagnosis of tumor tissues with QUESPOWR MRI

The Quantification of Exchange as a function of Saturation Power On the Water Resonance (QUESPOWR) method is introduced as a simple way to detect tissues with fast exchanging labile protons with small chemical shifts relative to water. QUESPOWR is analyzed by the linear HP-HW-QUESP method. Simulations and in vivo studies showed that QUESPOWR contrast is specific for tissues that exhibit low extracellular pH. QUESPOWR might offer sensitivity and specificity for tumor diagnosis.

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