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Abstract #1759

Salicylic Acid based CEST agents for assessing brain perfusion territory and blood-brain barrier permeability

Xiaolei Song 1,2 , Piotr Walczak 1,2 , Xing Yang 1 , Xiaowei He 1,3 , Jeff W.M. Bulte 1,2 , Monica Pearl 1 , Peter C.M. van Zijl 1,2 , Martin Pomper 1 , Michael T. McMahon 1,2 , and Mirosław Janowski 1,4

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3 School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi, China, 4 NeuroRepair Department, MMRC, PAS, Warsaw, Poland

We used aspirin analogues as CEST contrast agents for visualizing transcatheter brain perfusion territory. During intra-arterial infusion of these contrast agents, perfused brain parenchyma was highlighted in CEST images, with the contrast quickly dropping to baseline after infusion discontinuation. Three aspirin analogues with distinct chemical shifts were evaluated. They were detectable with the dose of ~11mg/kg producing >5% contrast.. Upon intra-arterial infusion of high osmolality mannitol, BBB disruption and parenchymal retention of contrast agents was observed with the territory matching that highlighted by control Gd-DTPA. When subsequently infusing two agents, multi-color CEST imaging allowed differentiation of their perfusion territories.

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