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Abstract #1760

Iopamidol CEST for pH mapping on a 7T scanner: phantom and normal mice kidneys in vivo study

Wei Hu 1 , Phillip Zhe Sun 2 , and Renhua Wu 3

1 the Second Affiliated Hospital of Shantou University Medical College, Shangtou, GuangDong, China, 2 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 3 Shantou University Medical College, Shantou, Guangdong, China

Human tissue lesions are often associated with cell internal and external disturbance of pH, and most of them showed the pHe value decreased .1 Therefore the determination of pHe in the tissue will have certain value for early diagnosis and identify of diseases. Up to now, the Iopamidol as a CEST imaging contrast agents have been reported.1-3 The aim of this study was to measure pH in vitro and in normal mice kidneys with Iopamidol use a new method and more simple ratiometric method on a 7T scanner3.

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