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Abstract #1761

Topiramate Induced Intracellular Acidification in Brain Tumors: In-vivo Detection Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Kamini Yogesh Marathe 1,2 , Nevin McVicar 1,2 , Alex Li 2 , Mojmir Suchy 3 , Miranda Bellyou 2 , Susan Meakin 2,4 , and Robert Bartha 1,2

1 Medical Biophysics, Western University, London, Ontario, Canada, 2 Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada, 3 Chemistry, Western University, London, Ontario, Canada, 4 Biochemistry, Western University, London, Ontario, Canada

Lonidamine which is previously used to quantify tumor selective acidification (decrease in intracellular pH(pHi)), using a novel chemical exchange saturation (CEST) method called amine and amide independent detection (AACID) CEST, is currently not approved to use in humans. Present study uses the antiepileptic drug, Topiramate, to quantify tumor selective acidification using AACID method in mouse model of cancer. After a single dose of topiramate, significant decrease in tumor pHi was evident. Further study on tumor selective acidification by topiramate is needed to determine whether AACID/CEST effects can be used for tumor detection and monitoring tumor response to treatment.

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