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Abstract #1762

Sensitivity of CEST MRI for absolute pH measurement in brain metastases

Kevin Ray 1 , James Larkin 1 , Yee Kai Tee 2,3 , Alexandr Khrapitchev 1 , Michael Chappell 3 , and Nicola Sibson 1

1 CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2 Department of Mechatronics and Biomedical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kuala Lumpur, Malaysia, 3 Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

CEST-MRI has emerged as a potential in vivo pH measurement method, but several confounding factors make absolute pH mapping difficult. Non-invasive mapping of pH would be useful in the clinic, particularly in the treatment of brain metastases. We aimed to determine the sensitivity of CEST to changes in pH, proton concentration, T 1 and T 2 in phantom models of mouse brain and metastatic breast tumour cells. Three analyses were used to measure CEST effects, and comparisons drawn. PTR* was found to be the most sensitive analysis metric, with the potential to measure pH changes on the order of 0.1pH units.

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