Abstract #1771
Effects of Water Proton Concentration and Water T1 Changes on APT and NOE Imaging Signals in Gliomas
Dong-Hoon Lee 1 , Hye-Young Heo 1 , Kai Zhang 1 , Yi Zhang 1 , Shanshan Jiang 1 , and Jinyuan Zhou 1
1
Division of MR Research, Department of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States
Amide proton transfer (APT) imaging can provide
endogenous contrast related to the mobile amide proton
content, amide proton exchange rate, and several other
possible tissue and experimental parameters. Here, the
correlations between APT and water proton concentration
and T1 were assessed using quantified APT based on the
extrapolated semi-solid magnetization transfer reference
(EMR) method. The results indicated no significant
correlations between APT/NOE signals and the combined
effect of water concentration and T1. The observed APT
hyper-intensities in tumor are primarily related to the
mobile amide proton content and/or the amide proton
exchange rate.
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