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Abstract #1771

Effects of Water Proton Concentration and Water T1 Changes on APT and NOE Imaging Signals in Gliomas

Dong-Hoon Lee 1 , Hye-Young Heo 1 , Kai Zhang 1 , Yi Zhang 1 , Shanshan Jiang 1 , and Jinyuan Zhou 1

1 Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Amide proton transfer (APT) imaging can provide endogenous contrast related to the mobile amide proton content, amide proton exchange rate, and several other possible tissue and experimental parameters. Here, the correlations between APT and water proton concentration and T1 were assessed using quantified APT based on the extrapolated semi-solid magnetization transfer reference (EMR) method. The results indicated no significant correlations between APT/NOE signals and the combined effect of water concentration and T1. The observed APT hyper-intensities in tumor are primarily related to the mobile amide proton content and/or the amide proton exchange rate.

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