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Abstract #1770

CEST and FLEX MRI for detection of CNS graft rejection

Sujith V Sajja 1,2 , Guanshu Liu 1,3 , Nirbhay Yadav 1,3 , Jiadi Xu 3 , Antje Arnold 1,2 , Anna Jablonska 1,2 , Michael McMahon 1,3 , Peter van Zijl 1,3 , Jeff Bulte 1,2 , Piotr Walczak 1,4 , and Miroslaw Janowski 1,5

1 Dept. of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, United States, 3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4 Department of Radiology, University of Warmia and Mazury, Olsztyn, Poland, 5 NeuroRepair Department, Polish Academy of Sciences, Warsaw, Poland

Conventional imaging such T1, T2 has been widely used to study gross anatomical changes and edema in brain. Stem cell transplantation has become attractive for regenerative medicine, but, grafts take months to years to become fully functional and could be rejected during this process. Non-invasive modalities to study CNS graft rejection clinically are currently unavailable. Progress in MR is providing access to molecular level changes including graft rejection process. Here we show that CEST and FLEX MRI may aid in detection of the process of rejection that could be tailored to individual grafts within the paradigm of personalized medicine.

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