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Abstract #1769

Breath-hold CEST-MRI of Liver Cirrhosis: A Clinical Feasibility Study

Xin Chen 1 , Weibo Chen 2,3 , Guangbin Wang 1 , Jianhua Lu 4 , Jinyuan Zhou 5 , Guang Jia 4,6 , and Jianqi Li 3

1 Shangdong Medical Imaging Research Institute, Shangdong University, Jinan, Shandong, China, 2 Philips Healthcare, Shanghai, China, 3 Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, 4 Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, United States, 5 Johns Hopkins University, Baltimore, MD, United States, 6 Pennington Biomedical Research Center, Baton Rouge, LA, United States

Liver cirrhosis is one type of glycogen storage disease without an increased amount of glycogen. Instead, the glycogen that does build up in the liver has very long outer branches, which may have a significant contribution to the transfer ratio of hydroxyl protons in CEST-MRI measurements. We have shown that it is clinically feasible to obtain CEST spectra in the liver with the breath-hold technique. Liver cirrhosis exhibited a significantly higher MTR at the resonance frequency of hydroxyl protons (1.2ppm), indicating a higher concentration of glycogen outer branches in liver cirrhosis.

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