Abstract #1768
Cardiac CEST imaging of diffuse fibrosis
Scott William Thalman 1,2 , Zhengshi Yang 1 , Andrea Mattingly 1 , and Moriel Vandsburger 1,3
1
Saha Cardiovascular Research Center,
University of Kentucky, Lexington, Kentucky, United
States,
2
Department
of Biomedical Engineering, University of Kentucky,
Lexington, Kentucky, United States,
3
Department
of Physiology, University of Kentucky, Lexington,
Kentucky, United States
Using a novel cardiac chemical exchange saturation
transfer (CEST) pulse sequence, we have demonstrated
changes in the magnetization transfer ratio (MTR) of
diffuse fibrosis in the myocardium of a mouse model of
chronic Angiotensin II stimulation. AngII treated mice
exhibit reduced levels of MTR (9.64 2.81%) compared to
saline treated (19.4 1.99%) and control mice (17.5
3.15%). This is due to an increase in the extracellular
water volume that results in reduced magnetization
transfer between the matrix macromolecules and bulk
water. This technique has the potential to enable
gadolinium-free imaging of diffuse fibrosis.
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