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Abstract #1767

Dynamic Glucose Enhanced (DGE) MRI for Imaging Brain Cancer

Xiang Xu 1,2 , Kannie WY Chan 1,2 , Linda Knutsson 3 , Dmitri Artemov 1,4 , Jiadi Xu 1,2 , Guanshu Liu 1,2 , Yoshi Kato 1,4 , Bachchu Lal 5,6 , John Laterra 5,6 , Michael T McMahon 1,2 , and Peter van Zijl 1,2

1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Johns Hopkins Medicine, Baltimore, MD, United States, 3 Department of Medical Radiation Physics, Lund University, Lund, Sweden, 4 Division of Cancer Imaging Research and JHU In Vivo Cellular Molecular Imaging Center, Johns Hopkins Medicine, MD, United States, 5 Department of Neurology, Kennedy Krieger Institute, MD, United States, 6 Department of Neuroscience, Kennedy Krieger Institute, MD, United States

Altered perfusion and uptake of glucose are hallmarks of tumors and there is a need for MRI methods revealing tumor perfusion, permeability and aggressiveness. We employed chemical exchange saturation transfer (CEST) MRI to dynamically study the delivery and uptake of D-glucose in an orthotopic glioblastoma model and compared this with dynamic contrast enhanced (DCE) MRI with GdDTPA. Dynamic Glucose Enhanced (DGE) data showed a prolonged uptake of glucose in tumors as compared to normal brain tissue, and compared well to DCE in identifying the tumor. The results indicate the feasibility for using D-glucose as an MRI perfusion agent for tumor assessment. #Both authors contributed equally *To whom correspondence may be addressed: Email:;

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