Abstract #1767
Dynamic Glucose Enhanced (DGE) MRI for Imaging Brain Cancer
Xiang Xu 1,2 , Kannie WY Chan 1,2 , Linda Knutsson 3 , Dmitri Artemov 1,4 , Jiadi Xu 1,2 , Guanshu Liu 1,2 , Yoshi Kato 1,4 , Bachchu Lal 5,6 , John Laterra 5,6 , Michael T McMahon 1,2 , and Peter van Zijl 1,2
1
Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins Medicine,
Baltimore, MD, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute Johns Hopkins Medicine,
Baltimore, MD, United States,
3
Department
of Medical Radiation Physics, Lund University, Lund,
Sweden,
4
Division
of Cancer Imaging Research and JHU In Vivo Cellular
Molecular Imaging Center, Johns Hopkins Medicine, MD,
United States,
5
Department
of Neurology, Kennedy Krieger Institute, MD, United
States,
6
Department
of Neuroscience, Kennedy Krieger Institute, MD, United
States
Altered perfusion and uptake of glucose are hallmarks of
tumors and there is a need for MRI methods revealing
tumor perfusion, permeability and aggressiveness. We
employed chemical exchange saturation transfer (CEST)
MRI to dynamically study the delivery and uptake of
D-glucose in an orthotopic glioblastoma model and
compared this with dynamic contrast enhanced (DCE) MRI
with GdDTPA. Dynamic Glucose Enhanced (DGE) data showed
a prolonged uptake of glucose in tumors as compared to
normal brain tissue, and compared well to DCE in
identifying the tumor. The results indicate the
feasibility for using D-glucose as an MRI perfusion
agent for tumor assessment. #Both authors contributed
equally *To whom correspondence may be addressed: Email:
pvanzijl@mri.jhu.edu; kanniec@mri.jhu.edu
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