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Abstract #1766

GlucoCEST as method for early detection of renal allograft rejection

Annika Busch 1 , Dominik Kentrup 2 , Helga Pawelski 2 , Nirbhay N. Yadav 3,4 , Guanshu Liu 3,4 , Peter C.M. van Zijl 3,4 , Stefan Reuter 2 , and Verena Hoerr 1,5

1 Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany, 2 Department of Medicine D - Experimental Nephrology, University Hospital Muenster, Muenster, Germany, 3 Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 4 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, United States, 5 Institute of Medical Microbiology, Jena University Hospital, Jena, Germany

In this small animal study we implemented and validated glucoCEST MRI for early detection and diagnosis of renal allograft rejection in a rat model. By using an optimized glucose infusion protocol which led to an increased and constant blood glucose level over MR measurement time, we obtained increased CEST contrast in pelvis and cortex for renal allografts undergoing rejection on day four post transplantation, compared to native kidneys. Calculated CEST-intensity ratios of transplanted and native kidneys were in good agreement with data of previous PET studies.

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