Abstract #1765
Glutamate CEST MRI in MPTP Mouse Model of Parkinsons Disease
Puneet Bagga 1 , Rachelle Crescenzi 1 , Guruprasad Krishnamoorthy 1 , Ravi Prakash Reddy Nanga 1 , Sidyarth Garimall 1 , Kevin DAquilla 1 , Damodara Reddy 1 , Joel H Greenberg 2 , John A Detre 2 , Hari Hariharan 1 , and Ravinder Reddy 1
1
Department of Radiology, University of
Pennsyvania, Philadelphia, Pennsylvania, United States,
2
Department
of Neurology, University of Pennsyvania, Philadelphia,
Pennsylvania, United States
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
causes selective dopaminergic death in the substantia
nigra and is used as an animal model for Parkinsons
disease (PD). Recent studies have shown that
exchangeable amine protons on glutamate (Glu) exhibit a
concentration dependent chemical exchange saturation
transfer (CEST) effect with surrounding water protons
(GluCEST). Here, we apply GluCEST, a novel non-invasive
MRI technique, in an MPTP mouse model of PD. GluCEST
imaging demonstrates ~13% elevation in GluCEST contrast
in striatum of PD mice in agreement with
1
H
MR spectroscopy.
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