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Abstract #1765

Glutamate CEST MRI in MPTP Mouse Model of Parkinsons Disease

Puneet Bagga 1 , Rachelle Crescenzi 1 , Guruprasad Krishnamoorthy 1 , Ravi Prakash Reddy Nanga 1 , Sidyarth Garimall 1 , Kevin DAquilla 1 , Damodara Reddy 1 , Joel H Greenberg 2 , John A Detre 2 , Hari Hariharan 1 , and Ravinder Reddy 1

1 Department of Radiology, University of Pennsyvania, Philadelphia, Pennsylvania, United States, 2 Department of Neurology, University of Pennsyvania, Philadelphia, Pennsylvania, United States

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes selective dopaminergic death in the substantia nigra and is used as an animal model for Parkinsons disease (PD). Recent studies have shown that exchangeable amine protons on glutamate (Glu) exhibit a concentration dependent chemical exchange saturation transfer (CEST) effect with surrounding water protons (GluCEST). Here, we apply GluCEST, a novel non-invasive MRI technique, in an MPTP mouse model of PD. GluCEST imaging demonstrates ~13% elevation in GluCEST contrast in striatum of PD mice in agreement with 1 H MR spectroscopy.

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