Abstract #1764
31 P MRS and Creatine CEST: A Method to Monitor Creatine Kinase Metabolism in a Perfused Heart Model
Kevin D'Aquilla 1 , Rong Zhou 1 , Hari Hariharan 1 , Neil Wilson 1 , and Ravinder Reddy 1
1
Center for Magnetic Resonance and Optical
Imaging, Department of Radiology, University of
Pennsylvania, Philadelphia, PA, United States
Creatine Chemical Exchange Saturation Transfer (CrCEST),
in conjunction with traditional 31P MRS methods, has
recently been shown to be able to evaluate the activity
of creatine kinase in the human calf muscle. Although
study of cardiac bioenergetics using CrCEST is an
enticing prospect, a number of difficulties exist in
translating this method to the human heart in vivo. This
work, utilizing an ex vivo perfused rat heart model at
9.4T, represents a preliminary step towards applying
CrCEST to the study of cardiac metabolism, including the
heart's response to ischemia, infarction, and adverse
biochemical and physical stressors.
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