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Abstract #1764

31 P MRS and Creatine CEST: A Method to Monitor Creatine Kinase Metabolism in a Perfused Heart Model

Kevin D'Aquilla 1 , Rong Zhou 1 , Hari Hariharan 1 , Neil Wilson 1 , and Ravinder Reddy 1

1 Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Creatine Chemical Exchange Saturation Transfer (CrCEST), in conjunction with traditional 31P MRS methods, has recently been shown to be able to evaluate the activity of creatine kinase in the human calf muscle. Although study of cardiac bioenergetics using CrCEST is an enticing prospect, a number of difficulties exist in translating this method to the human heart in vivo. This work, utilizing an ex vivo perfused rat heart model at 9.4T, represents a preliminary step towards applying CrCEST to the study of cardiac metabolism, including the heart's response to ischemia, infarction, and adverse biochemical and physical stressors.

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