Abstract #1773
Isolated amide proton CEST contrast at 7 T correlates with contrastenhanced T 1 weighted images of tumor patients
Johannes Windschuh 1 , Steffen Goerke 1 , Jan-Eric Meissner 1 , Alexander Radbruch 2,3 , Peter Bachert 1 , and Moritz Zaiss 1
1
Division of Medical Physics in Radiology,
German Cancer Research Center (DKFZ), Heidelberg,
Baden-Wrttemberg, Germany,
2
Department
of Neuroradiology, University of Heidelberg Medical
Center, Heidelberg, Baden-Wrttemberg, Germany,
3
Department
of Radiology, German Cancer Research Center (DKFZ),
Heidelberg, Baden-Wrttemberg, Germany
We present a method that isolates the
in
vivo
CEST
effect of amide protons at 7 T from the underlying
aromatic NOE. This results in a contrast solely
dependent on pH and amide proton concentration, that
shows excellent correlation with the tumor ring
enhancement of T
1
-weighted gadolinium
contrast-enhanced images. This is shown for 4 patients
with newly diagnosed and histologically proven
glioblastoma in comparison to the asymmetry based CEST
contrast MTR
asym
.
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