Frequency-Encoded MRI-CEST Agents Based on Paramagnetic Liposomes/RBC Aggregates

Positively charged paramagnetic liposomes have been electrostatically bound to the membrane of RBCs. These aggregates yield two CEST pools represented by liposomal water protons (LipoCEST) and cytoplasmatic water protons (ErythroCEST), respectively. When administrated In vivo intravenously, these aggregates report about the vascular volume ans the residual LipoCEST effect informs about the presence of released liposomes in the tumor region . the LipoCEST/RBC aggregates represent a new way to label cells, a new route to improve the circulation lifetime of the liposomes and a procedure to assess the de-assembly of the aggregates and the accumulation of the liposomes in the tumor.

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