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Abstract #1878

19 F-Hyperpolarized Structures as Markers for the Improved Detection of Amyloid Plaques

Ute Bommerich 1,2 , Thomas Trantzschel 1 , Markus Plaumann 1 , Denise Lego 2 , Gerd Buntkowsky 3 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , and Johannes Bernarding 1

1 Institute for Biometrics and Medical Informatics, Otto von Guericke University Magdeburg, Magdeburg, Saxony-Anhalt, Germany, 2 Special Lab Non-invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany, 3 Eduard-Zintl-Institute for Inorganic Chemistry, Technical University Darmstadt, Hesse, Germany, 4 Institute for Physical and Theoretical Chemistry, University Bonn, North Rhine-Westphalia, Germany

Fluorinated bis(styryl)benzene derivatives can improve the MR detection of amyloid plaques, that are supposed to play an important role in the progression of Alzheimers disease. These molecules enable 19 F-MRI experiments with optimal contrast only restricted by the concentration of the applied markers. An increase of MR-sensitivity by orders of magnitude makes Parahydrogen Induced Polarization (PHIP) a promising tool. It is demonstrated that hyperpolarization of 19 F nuclei in molecules that are structurally closely related to amyloid markers is feasible. This leads to an in-phase signal with improved intensity which could be further increased by a field cycling step.

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