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Abstract #1879

PHIP hyperpolarization of linear and branched fluorinated alkanes as well as their interaction with cyclodextrins

Markus Plaumann 1 , Thomas Trantzschel 1 , Jan Wstemann 1 , Denise Lego 2 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , Gerd Buntkowsky 3 , Johannes Bernarding 1 , and Ute Bommerich 1,2

1 Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Saxony-Anhalt, Germany, 2 Special Lab Non-Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany, 3 Eduard-Zintl-Institute for Inorganic Chemistry, Technical University Darmstadt, Darmstadt, Hesse, Germany, 4 Institute of Physical and Theoretical Chemistry, University Bonn, Bonn, North Rhine-Westphalia, Germany

The chemical inertness of fluorinated alkanes makes them ideal for in vivo application, e.g. molecular imaging. Here, the hyperpolarization of four semifluorinated substrates is presented by using the parahydrogen induced polarization (PHIP). 1H,1H,2H-perfluorohexane, 1H,1H,2H-perfluorooctane, 1H,1H,2H-perfluorodecane and perfluoro-(4-methylpentane) are chosen to demonstrate the polarization transfer from protons over a chain of CF 2 respectively CF groups to the end-standing CF 3 groups, which leads in a nonuniform distribution of the polarization. Additionally studies in presence of cyclodextrin derivatives show a molecular interaction between cyclodextrin and the lipophilic semifluorinated substrate. This allows the transport into an aqueous solution, which is important for biomedical applications.

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