Abstract #1879
PHIP hyperpolarization of linear and branched fluorinated alkanes as well as their interaction with cyclodextrins
Markus Plaumann 1 , Thomas Trantzschel 1 , Jan Wstemann 1 , Denise Lego 2 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , Gerd Buntkowsky 3 , Johannes Bernarding 1 , and Ute Bommerich 1,2
1
Department for Biometrics and Medical
Informatics, Otto-von-Guericke University Magdeburg,
Magdeburg, Saxony-Anhalt, Germany,
2
Special
Lab Non-Invasive Brain Imaging, Leibniz Institute for
Neurobiology, Magdeburg, Saxony-Anhalt, Germany,
3
Eduard-Zintl-Institute
for Inorganic Chemistry, Technical University Darmstadt,
Darmstadt, Hesse, Germany,
4
Institute
of Physical and Theoretical Chemistry, University Bonn,
Bonn, North Rhine-Westphalia, Germany
The chemical inertness of fluorinated alkanes makes them
ideal for in vivo application, e.g. molecular imaging.
Here, the hyperpolarization of four semifluorinated
substrates is presented by using the parahydrogen
induced polarization (PHIP). 1H,1H,2H-perfluorohexane,
1H,1H,2H-perfluorooctane, 1H,1H,2H-perfluorodecane and
perfluoro-(4-methylpentane) are chosen to demonstrate
the polarization transfer from protons over a chain of
CF
2
respectively
CF groups to the end-standing CF
3
groups,
which leads in a nonuniform distribution of the
polarization. Additionally studies in presence of
cyclodextrin derivatives show a molecular interaction
between cyclodextrin and the lipophilic semifluorinated
substrate. This allows the transport into an aqueous
solution, which is important for biomedical
applications.
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