Abstract #1882
Generation of hyperpolarized bicarbonate in large concentrations to image pH
Rajat K Ghosh 1 , Mehrdad Pourfathi 1 , Stephen J Kadlecek 1 , and Rahim R Rizi 1
1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
Synopsis: Hyperpolarized (HP) bicarbonate has been used
to image pH in vivo. However, its utilization has been
limited by difficulties in generating high polarizations
and concentrations. In this work, we describe a new
technique for generating HP bicarbonate by
de-carboxylating HP pyruvate. HP bicarbonate produced in
this manner is then used to image pH in rat lungs at
sub-mm resolutions. Production of HP bicarbonate through
direct polarization is currently limited to
concentrations of ~100mM. In contrast, our indirect
decarboxylation approach generates 100-400mM
bicarbonate, further increasing signal to allow for
high-resolution pH imaging.
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