Generation of hyperpolarized bicarbonate in large concentrations to image pH

Synopsis: Hyperpolarized (HP) bicarbonate has been used to image pH in vivo. However, its utilization has been limited by difficulties in generating high polarizations and concentrations. In this work, we describe a new technique for generating HP bicarbonate by de-carboxylating HP pyruvate. HP bicarbonate produced in this manner is then used to image pH in rat lungs at sub-mm resolutions. Production of HP bicarbonate through direct polarization is currently limited to concentrations of ~100mM. In contrast, our indirect decarboxylation approach generates 100-400mM bicarbonate, further increasing signal to allow for high-resolution pH imaging.

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