Abstract #1883
Hyperpolarized [2- 13 C]Dihydroxyacetone: Monitoring Hepatic Gluconeogenesis in Real-Time
Karlos X Moreno 1 , Santhosh Satapati 1 , Ralph J DeBerardinis 2 , Shawn C Burgess 1 , Craig R Malloy 1 , and Matthew E Merritt 1
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, TX, United States,
2
Children's
Medical Center Research Institute, UT Southwestern
Medical Center, Dallas, TX, United States
Direct observation of hyperpolarized glucose from a
gluconeogenic substrate has not previously been
observed. Isolated mouse livers perfused in a
gluconeogenic or glycogenolytic state were injected with
hyperpolarized [2-
13
C]dihydroxyacetone. In
each condition, hyperpolarized glucose signals were
observed. Purified effluent glucose confirmed the
enrichment. Minimal differences in hyperpolarized
glucose signals between the two conditions were
observed. Triose intermediates of glycolysis showed
large differences, the glycogenolytic condition having
greater signals. This is the first study to demonstrate
direct gluconeogenesis using hyperpolarization methods.
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