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Abstract #1886

Development of Hyperpolarized 13C-MRS Probes for Oxidative Stress measurement

Arif Wibowo 1 , Jae Mo Park 2 , Ralph Hurd 3 , Graham F Sommer 4 , Chaitan Khosla 5 , and Daniel M Spielman 6

1, Stanford, CA, United States, 2 Stanford, CA, United States, 3 GE healthcare, CA, United States, 4 Diagnostic Radiology, Stanford University, CA, United States, 5 Chemistry and ChEM-H, Stanford University, CA, United States, 6 Radiology, Stanford University, CA, United States

In this study, we evaluated the potential of cysteine (Cys), N-acetyl cysteine (NAC), and Mercaptopyruvate (MCP as hyperpolarized 13C substrate for assessing oxidative stress (OS) in vivo. Of these, MCP was identified as a viable substrate for in vitro OS assessment, and we are currently developing large-scale MCP synthesis for testing the potential of this substrate for in vivo OS measurements.

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