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Abstract #1887

Quantitative analysis for hyperpolarized 13 C-pyruvate imaging: comparison of methods on a clinical system.

Charlie J Daniels 1 , Mary A McLean 2 , Nicholas McGlashan 1 , Martin J Graves 1 , Fraser J Robb 3 , David J Lomas 1 , Rolf F Schulte 4 , Kevin M Brindle 2 , and Ferdia A Gallagher 1,2

1 Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 3 USA Instruments Inc., Aurora, Ohio, United States, 4 GE Global Research, Munich, Germany

Hyperpolarized imaging with 13 C-labelled endogenous molecules is on the verge of clinical translation. A simple, robust and objective method of quantitative analysis is required to process hyperpolarized data clinically, however there is currently debate over the best methods to apply. We assessed four quantitative methods by imaging conversion of [1- 13 C]pyruvate to [1- 13 C]lactate using a clinical polarizer system at 3 T and a pyruvate concentration predicted for future patient studies. We conclude that extracting data from a single voxel is sufficiently robust and suggest the area under the curve ratio be taken forward as a standardised clinical parameter.

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