31P Dynamic Nuclear Polarization Applied to Phosphonates for MRS/MRI Applications.
Roha Afzal 1,2 , Gary V. Martinez 1 , and Robert J. Gillies 1
Cancer Imaging and Metabolism, H.Lee Moffitt
Cancer Centre, Tampa, Florida, United States,
and Biomedical Engineering, University of South Florida,
Tampa, Florida, United States
This study demonstrates the first application of 31P
Dynamic Nuclear Polarization to the Phosphonates. The
experimental conditions (glassing agents, radicals
microwave irradiation frequencies, maximum polarization
build-up time, etc.) were optimized for the
hyperpolarization of Dimethyl Methyl Phosphonate. An
in-vivo experiment was then carried out at these optimum
conditions and the hyperpolarized 31P image and signal
were observed in the animal.
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