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Abstract #1888

31P Dynamic Nuclear Polarization Applied to Phosphonates for MRS/MRI Applications.

Roha Afzal 1,2 , Gary V. Martinez 1 , and Robert J. Gillies 1

1 Cancer Imaging and Metabolism, H.Lee Moffitt Cancer Centre, Tampa, Florida, United States, 2 Chemical and Biomedical Engineering, University of South Florida, Tampa, Florida, United States

This study demonstrates the first application of 31P Dynamic Nuclear Polarization to the Phosphonates. The experimental conditions (glassing agents, radicals microwave irradiation frequencies, maximum polarization build-up time, etc.) were optimized for the hyperpolarization of Dimethyl Methyl Phosphonate. An in-vivo experiment was then carried out at these optimum conditions and the hyperpolarized 31P image and signal were observed in the animal.

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