Abstract #1889
Hepatic Metabolism of Hyperpolarized [1- 13 C]Pyruvate in the Zucker Rat
Jian-Xiong Wang 1,2 , Leila Fidelino 3 , Karlos Moreno 3 , A. Dean Sherry 3,4 , Craig Malloy 3,5 , and Matthew E Merritt 1,6
1
AIRC, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Radiology,
UT Southwestern Medical Center, Dallas, TX, United
States,
3
AIRC,
UT Southwestern Medical Center, TX, United States,
4
Chemistry,
University of Texas at Dallas, TX, United States,
5
Internal
Medicine, UT Southwestern Medical Center, TX, United
States,
6
Radiology,
UT Southwestern Medical Center, Dallas, United States
Hyperpolarized [1-
13
C]pyruvate can be
metabolized in the liver via flux through pyruvate
dehydrogenase (PDH) or pyruvate carboxylase (PC). In
normal rats, PDH dominates the generation of [
13
C]bicarbonate
in
vivo
. The Zucker rat is a model of diabetes that
displays high levels of hepatic gluconeogenesis. In
fasting, [
13
C]bicarbonate production is
maintained, contrary to the normal animal. Sources of
the [
13
C]bicarbonate production (PDH versus
PC) will be identified.
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