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Abstract #1890

Low cell number perfusion bioreactor system for hyperpolarized MRS in a MRI setting

Lotte Bonde Bertelsen 1 , Simon Lauritsen 1 , Christoffer Laustsen 1 , Preben Daugaard 1 , Xiaolu Zhang 1 , and Hans Stdkilde-Jrgensen 1

1 The MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Aarhus, Denmark

Development of a MR-compatible bioreactor system for measuring metabolic fluxes in cells grown in scaffold makes it possible to examine various cell types with different hyperpolarized 13 C bio-probes. The 3D printed scaffold system facilitates a dynamic cell culture environment with controlled nutrient flow, oxygen supply and a large surface area for growth of adherent cells with minimal disturbance of the cells. Ongoing studies are focusing on evaluation of low cell numbers in scaffold and in suspension in this bioreactor design.

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