Abstract #1891
Investigation of Metabolic Changes in STZ Induced Diabetic Rats with Hyperpolarized [1-13C]Acetate
Ulrich Koellisch 1 , Christoffer Laustsen 2 , Thomas S. Nrlinger 2 , Concetta V. Gringeri 3 , Marion I. Menzel 4 , Rolf F. Schulte 4 , Axel Haase 1 , and Hans Stdkilde-Jrgensen 2
1
Institute of Medical Engineering, Technische
Universitt Mnchen, Munich, Germany,
2
MR
Research Centre, Aarhus University, Aarhus, Denmark,
3
Nuklearmedizinische
Klinik und Poliklinik, Technische Universitt Mnchen,
Germany,
4
GE
Global Research, Munich, Germany
In the metabolism of acetate several enzymes are
involved, which play an important role for free fatty
acid oxidation. Therefore it might serve as a marker for
pathological changes of cells' fuel selection in
particular in the myocardium. The goal of this study was
to investigate whether the ratio of acetylcarnitine to
acetate could serve as a marker for myocardial, hepatic
and renal metabolic changes under Streptozotocin induced
diabetes in vivo.
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