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Abstract #1891

Investigation of Metabolic Changes in STZ Induced Diabetic Rats with Hyperpolarized [1-13C]Acetate

Ulrich Koellisch 1 , Christoffer Laustsen 2 , Thomas S. Nrlinger 2 , Concetta V. Gringeri 3 , Marion I. Menzel 4 , Rolf F. Schulte 4 , Axel Haase 1 , and Hans Stdkilde-Jrgensen 2

1 Institute of Medical Engineering, Technische Universitt Mnchen, Munich, Germany, 2 MR Research Centre, Aarhus University, Aarhus, Denmark, 3 Nuklearmedizinische Klinik und Poliklinik, Technische Universitt Mnchen, Germany, 4 GE Global Research, Munich, Germany

In the metabolism of acetate several enzymes are involved, which play an important role for free fatty acid oxidation. Therefore it might serve as a marker for pathological changes of cells' fuel selection in particular in the myocardium. The goal of this study was to investigate whether the ratio of acetylcarnitine to acetate could serve as a marker for myocardial, hepatic and renal metabolic changes under Streptozotocin induced diabetes in vivo.

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