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Abstract #1893

Chemical exchange sensitive Spin-lock MRI of 3-O-methyl-D-glucose transport in brain

Hunter Mehrens 1 , Tao Jin 1 , and Seong-Gi Kim 1,2

1 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Center for Neuroscience Imaging Research, Institue for Basic Science, SKKU, Suwon, Korea

Recent studies showed an increase of chemical exchange-sensitive spin-lock (CESL) MRI signal during administration of 2-deoxy-glucose (2DG) with high sensitivity. However, the toxicity of 2DG is a concern for its clinical and preclinical application. 3-O-methyl-D-glucose (3OMG) is a non-metabolizable glucose analogue with minimal toxicity, therefore, it may have better potential as a contrast agent for the study of glucose transport. In this work, we demonstrated that 3OMG has similar chemical exchange properties as 2DG and glucose, and unique advantages relative to 2DG and glucose for in vivo studies.

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