Abstract #1894
New PARACEST MRI Contrast Agents Based on the DOTMA Scaffold
Mojmir Suchy 1 , Alex X. Li 2 , Robert Bartha 2 , and Robert H. E. Hudson 1
1
Department of Chemistry, University of
Western Ontario, London, Ontario, Canada,
2
Centre
for Functional and Metabolic Mapping, University of
Western Ontario, London, Ontario, Canada
A synthetic methodology has been developed for the
preparation of Tm(III) complexes derived from DOTMA as
new type of PARACEST MRI contrast agent. Agents were
identified that possessed CEST peaks at chemical shifts
beyond the frequency range of the endogenous
macromolecule magnetization transfer. The CEST effects
of these agents investigated were found to be sensitive
to both temperature and pH.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
