New PARACEST MRI Contrast Agents Based on the DOTMA Scaffold
Mojmir Suchy 1 , Alex X. Li 2 , Robert Bartha 2 , and Robert H. E. Hudson 1
Department of Chemistry, University of
Western Ontario, London, Ontario, Canada,
for Functional and Metabolic Mapping, University of
Western Ontario, London, Ontario, Canada
A synthetic methodology has been developed for the
preparation of Tm(III) complexes derived from DOTMA as
new type of PARACEST MRI contrast agent. Agents were
identified that possessed CEST peaks at chemical shifts
beyond the frequency range of the endogenous
macromolecule magnetization transfer. The CEST effects
of these agents investigated were found to be sensitive
to both temperature and pH.
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