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Abstract #1894

New PARACEST MRI Contrast Agents Based on the DOTMA Scaffold

Mojmir Suchy 1 , Alex X. Li 2 , Robert Bartha 2 , and Robert H. E. Hudson 1

1 Department of Chemistry, University of Western Ontario, London, Ontario, Canada, 2 Centre for Functional and Metabolic Mapping, University of Western Ontario, London, Ontario, Canada

A synthetic methodology has been developed for the preparation of Tm(III) complexes derived from DOTMA as new type of PARACEST MRI contrast agent. Agents were identified that possessed CEST peaks at chemical shifts beyond the frequency range of the endogenous macromolecule magnetization transfer. The CEST effects of these agents investigated were found to be sensitive to both temperature and pH.

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