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Abstract #1895

Enriching Fluorine Nanoparticles with Saturated Phosphoethanolamines to Improve Dendritic Cell Detection by 19 F Magnetic Resonance In Vivo

Sonia Waiczies 1 , Stefano Lepore 1 , Min-Chi Ku 1 , Helmar Waiczies 1,2 , Conrad Martin 1 , Susanne Drechsler 1 , Karl Sydow 3 , Margitta Dathe 3 , Andreas Pohlmann 1 , and Thoralf Niendorf 1

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrck Center for Molecular Medicine, Berlin, Germany, Germany, 2 MRI.Tools GmbH, Berlin, Germany, 3 Leibniz-Institut fr Molekulare Pharmakologie, Berlin, Germany

Magnetic resonance (MR) methods to detect and quantify fluorine nuclei provide the opportunity to study the fate of cellular transplants in vivo. Challenges pertaining to MR signal sensitivity and cell detection exist. This study addresses these issues by examining the uptake mediating potential of nanoparticles enriched with phosphatidylethanolamines to improve dendritic cell detection.

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