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Abstract #1897

High Relaxivity MRI Contrast Agents based on a closo-borane platform

Shatadru Chakravarty 1,2 , Lixin Ma 1 , Lalit N. Goswami 1 , Satish S. Jalisatgi 1 , and M. Frederick Hawthorne 1

1 Radiology, International Institute of Nano and Molecular Medicine-University of Missouri-Columbia, Columbia, MO, United States, 2 Radiology, Michigan State University, East Lansing, MI, United States

The signal intensity and the overall detail and clarity of an image obtained in an MRI exam is enhanced spectacularly by the administration of chemical species known as Contrast Agent (CAs). Despite several years of research, the current batch of clinically approved CAs are mostly small molecular weight species that suffer from low relaxivity, poor tissue selectivity and extremely short intravascular half-lives. We herein report a novel class of CAs based on a closo-borane framework with multifold improvements in relaxivity. These multifunctional molecules are based on the novel and unique twelve-fold functionalization of closo-B12(OH)122- with a modified Gd- AAZTA chelate.

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