Abstract #1900
Organic radical contrast agents based on polyacetylenes containing 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO): targeted MR /optical bimodal imaging of folate receptor expressing HeLa tumors in vitro and in vivo
Lixia Huang 1 , Chenggong Yan 1 , Danting Cui 1 , Xiang Liu 1 , Xiaodan Lu 1 , Yichen Yan 2 , Xiangliang Tan 1 , Jun Xu 3 , Yingjie Mei 4 , Xinwei Lu 2 , Yikai Xu 1 , and Ruiyuan Liu 2
1
Department of Medical Imaging Center,
Nanfang Hospital, Southern Medical University,
Guangzhou, Guangdong, China,
2
School
of Pharmaceutical Sciences, Southern Medical University,
Guangzhou, Guangdong, China,
3
Department
of Hematology, Nanfang Hospital, Southern Medical
University, Guangzhou, Guangdong, China,
4
Philips
Healthcare, Guangzhou, Guangdong, China
Polyacetylenes containing
2,2,6,6-tetramethyl-piperidinooxy and poly(ethylene
glycol) conjugated with carboxyl fluorescein and folic
acid (FA) are synthesized by metathesis polymerization
of corresponding substituted acetylenes for targeted
bimodal MRI /optical imaging of tumors. In vitro studies
confirm excellent binding specificity and subsequent
enhanced cellular internalization of the targeted ORCAs
(PA-TEMPO-FI-FA). In vivo T1-weighted MRI and optical
imaging demonstrate the active tumor targeting ability
of PA-TEMPO-FI-FA to generate specific contrast
enhancement in mice bearing HeLa tumors. These results
indicate that the multifunctional ORCAs may provide a
tumor-targeted delivery platform for further molecular
imaging guided cancer therapy.
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