Abstract #1901
Detection of matrix metalloproteinases using an "on/off" 19 F MR probe
Alex John Taylor 1 , James Lee Krupa 2 , Huw Williams 3 , Dorothee P Auer 1 , Simon R Johnson 4 , Neil R Thomas 2 , and Henryk Michael Faas 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
School
of Chemistry, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
3
Centre
for Biomolecular Sciences, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom,
4
School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
A novel chemical sensor is presented which is able to
detect matrix metalloproteinases (MMPs) using
19
F
MR. The contrast mechanism uses an on/off principle
with paramagnetic gadolinium linked to a fluorine source
via an enzyme substrate. Two examples of synthesised
sensors are shown; one for MMPs 2 and 9, the other for
all types of MMP. Upon addition of MMP 9, both sensors
show an increased T
1
relaxation
time due to enzymatic cleavage which causes an increase
in the fluorine-gadolinium distance. Fluorine signal
intensity is also increased by a factor of 3.5 after MMP
addition.
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