Abstract #1902
PERFLUORO-15-CROWN-5-ETHER-LOADED HOLLOW MESOPOROUS SILICA SPHERES FOR 19F IN VIVO MRI
Ina Vernikouskaya 1,2 , Alexander Pochert 3 , Mika Linden 3 , and Volker Rasche 1,2
1
Internal Medicine II, University Hospital of
Ulm, Ulm, Baden-Wuerttemberg, Germany,
2
Small
Animal MRI, University of Ulm, Ulm, Baden-Wuerttemberg,
Germany,
3
Inorganic
Chemistry II, University of Ulm, Ulm,
Baden-Wuerttemberg, Germany
19F offers great potential for in vivo quantification
without any background signal. Perfluorocarbons (PFC)
are typically applied due to their high 19F density.
Mesoporous amorphous silica nanoparticles have attracted
a lot of interest as drug carriers. However more
attractive particle architecture would be hollow spheres
with a porous shell that would allow higher PFC loadings
per particles. 250nm-sized hollow mesoporous silica
spheres (HMSS) are loaded with
perfluoro-15-crown-5-ether (PFCE) and evaluated as a new
contrast agent. PFCE-HMSS was characterized using MRI.
19F MRS was performed for quantification of the fluorine
load. A good fluorine signal localized in the liver and
in the brown fat was detected in vivo.
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