Abstract #1903
Multifunctional Gd2O3-loaded nanoprobe for targeted molecular MR imaging
Xiang Liu 1 , Xiaodan Lu 1 , Chenggong Yan 1 , Danting Cui 1 , Yichen Yan 2 , Xinwei Lu 2 , Queenie Chan 3 , Jun Xu 4 , Yikai Xu 1 , and Ruiyuan Liu 2
1
Department of Medical Imaging Center,
Nanfang Hospital, Southern Medical University,
Guangzhou, Guangdong, China,
2
School
of Pharmaceutical Sciences, Southern Medical University,
Guangzhou, Guangdong, China,
3
Philips
Healthcare, HongKong, China,
4
Department
of Hematology, Nanfang Hospital, Southern Medical
University, Guangzhou, Guangdong, China
Multifunctional and folate (FA) modified gadolinium
oxide (Gd2O3) nanocarriers were developed for targeted
molecular MRI of FA receptor positive HeLa tumors.
Gd2O3-based nanoparticles were conjugated with
5(6)-carboxyfluorescein (FI) for fluorescence and
functionalized with poly(ethylene glycol) (PEG) segments
bearing FA group. Enhanced cellular uptake of the
targeted Gd2O3 nanocarriers in Hela tumor cells was
observed.in vitro. Moreover, the targeted Gd2O3
naoparticles showed more remarkable contrast enhancement
than the control probes according in vivo MRI. Thus,
these Gd2O3 nanoparticles may be a promising
nano-platform for combined targeted antitumor drug
delivery and molecular MRI cancer diagnosis in future
clinical applications.
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