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Abstract #1904

Facilitating the EPR Effect and Improving Tumor Penetration and Nanoparticle Delivery with Ultrafine Iron Oxide Nanoparticle as Observed via Its Dual-Contrast Effect

Jing Huang 1,2 , Liya Wang 1,2 , Hui Wu 1,2 , Lily Yang 3 , and Hui Mao 1,2

1 Laboratory of Functional-Molecular Imaging and Nanomedicine, Emory University School of Medicine, Atlanta, GA, United States, 2 Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States, 3 Surgery, Emory University, Atlanta, GA, United States

Engineered nanoparticles are delivered to the tumor mainly through the enhanced permeability and retention (EPR) effect, which is dependent on and limited by nanoparticle size. Here we report ultrafine iron oxide nanoparticles (uIONPs) with a core diameter of 3.5 nm and dual T1-T2 contrast to facilitate the EPR effect for improved MRI and drug delivery. uIONPs are highly dispersed in circulation but can undergo reversible self-clustering at pH below 7, when entering tumor interstitial space, leading to switching from bright T1 contrast to dark T2 contrast while promoting tumor accumulation by 1.6 fold compared to nanoparticles with larger sizes.

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