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Abstract #1905

Theranostic prospects of gadolinium-based mesoporous silica nanoparticle probes for functional MRI

Veronika Mamaeva 1,2 , Tina Pavlin 3,4 , Didem Sen Karaman 5 , Diti Desai 5 , Melanie Ostermann 1 , Jessica Rosenholm 5 , and Emmet McCormack 1,2

1 Department of Clinical Science, Hematology Section, University of Bergen, Bergen, Norway, 2 Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway, 3 Department of Biomedicine, Molecular Imaging Center, University of Bergen, Bergen, Norway, 4 Department of Radiology, Haukeland University Hospital, Bergen, Norway, 5 Laboratory of Physical Chemistry, bo Akademi University, Turku, Finland

A novel mesoporous silica nanoparticle MRI probe with theranostic prospects for targeted drug delivery was developed and applied to imaging of subcutaneous tumors in mice. Animals were injected either with Gd-doped MSNPs, pristine MSNPs, or Dotarem, and T1-weighted RARE images were collected pre- and at various time points post contrast injection. We observed a slight, but significant, increase of SI on T1-weighted images of GadoNPs-treated tumors at 24 hours. Conclusion: Gddoped MSNPs are retained for at least 96 hours in tumor tissue and can be visualized by MRI, suggesting feasibility of using this NP platform for future theranostic applications.

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