Meeting Banner
Abstract #1909

Engineering of a MRI Theranostic Agent for Detection and Treatment of Cerebrovascular Amyloid

Jens T Rosenberg 1,2 , Kristen MJ Ahlschwede 3,4 , Edward K Agyare 5 , Geoffery L Curran 4 , Samuel C Grant 1,2 , and Karunya K Kandimalla 3,4

1 National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2 Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 3 Pharmaceutics and Brain Barriers Research Center, University of Minnesota, Minneapolis, MN, United States, 4 Neurology, Neuroscience and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, United States, 5 College of Pharmacy and Pharmaceutical Science, Florida A&M University, Tallahassee, FL, United States

This work demonstrates a novel MRI-detectable multifunctional nanoparticle targeting cerebrovascular amyloids by conjugating Gd-DTPA with the amyloid antibody Ig 4.1 while at the same time providing drug delivery capabilities. This theranostic nanovehicle shows hypointense contrast for targeted cerebrovascular amyloids on MR microimages acquired at the ultrahigh field of 21.1 T. The approach potentially can provide a heretofore sought after diagnostic and therapeutic tool for cerebral amyloid angiopathy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here