Abstract #1922
Design of Implantable alginate MRI pH sensors for cell transplantation
Nikita Oskolkov 1,2 , Xiaolei Song 1,2 , Kannie W.Y. Chan 1,2 , Jeff W.M. Bulte 1,2 , and Michael T. McMahon 1,2
1
The Russell H. Morgan Department of
Radiology and Radiological Science, Johns Hopkins School
of Medicine, Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
Cell transplantation is an important strategy for
treating otherwise incurable diseases, with numerous
clinical trials now ongoing all over the world. Various
biocompatible materials have been designed to support
transplanted cells and protect them from the immune
system. Our previous study showed that alginate-based
hydrogels could be used for non-invasive monitoring of
hepatocytes cell death in vivo using pH sensitive CEST
magnetic resonance imaging (MRI) technique. In this
study we were interested in redesigning these for use on
lower field scanners, through incorporating salicylic
acid (SA)-based pH-nanosensors into the biomaterial
through dispersing SA-liposomes through alginate
capsules. These SA agents display CEST contrast at
high-frequency-offsets. In this abstract we show how
these can be used for non-invasive MRI imaging of
encapsulated cells.
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