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Abstract #1922

Design of Implantable alginate MRI pH sensors for cell transplantation

Nikita Oskolkov 1,2 , Xiaolei Song 1,2 , Kannie W.Y. Chan 1,2 , Jeff W.M. Bulte 1,2 , and Michael T. McMahon 1,2

1 The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

Cell transplantation is an important strategy for treating otherwise incurable diseases, with numerous clinical trials now ongoing all over the world. Various biocompatible materials have been designed to support transplanted cells and protect them from the immune system. Our previous study showed that alginate-based hydrogels could be used for non-invasive monitoring of hepatocytes cell death in vivo using pH sensitive CEST magnetic resonance imaging (MRI) technique. In this study we were interested in redesigning these for use on lower field scanners, through incorporating salicylic acid (SA)-based pH-nanosensors into the biomaterial through dispersing SA-liposomes through alginate capsules. These SA agents display CEST contrast at high-frequency-offsets. In this abstract we show how these can be used for non-invasive MRI imaging of encapsulated cells.

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