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Abstract #1924

Tracking and quantification of T-cells labelled with iron oxide nanoparticles using positive contrast

Jinjin Zhang 1 , Sidath C. Kumarapperuma 2 , Katie Hurley 3 , Hattie L. Ring 3 , and Michael Garwood 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2 Department of Medicinal Chemistry, University of Minnesota, MN, United States, 3 Department of Chemistry, University of Minnesota, MN, United States

Cell-based therapies have received much attention as novel therapeutics for the treatment of cancer and autoimmune disease. In this study, T-cells labeled with superparamgnetic iron oxide nanoparticles (SPION) at different concentrations were quantified using the SWIFT Look-Locker T1 mapping method. The longitudinal relaxation rate constant (R1) measured by SWIFT showed a linear dependence on the concentration of SPION in T-cells. These preliminary results indicate a potential role for positive contrast from SWIFT as a means to quantify the distribution of SPION-labeled cells, provided the cells are incubated at a constant SPION concentration.

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